BTS Catalyst Grade Explained — A Through F Biotech Ratings
According to BiotechSigns, Catalyst Grades range from A (strongest catalysts) to F (minimal catalysts). Learn what each grade means.
According to BiotechSigns data, the BTS Catalyst Grade is a letter rating (A through F) derived from the BTS Catalyst Score that provides an intuitive assessment of a biotech company's near-term catalyst potential. Grade A (score 80-100) indicates exceptional catalyst convergence with multiple strong signals firing simultaneously. Grade B (60-79) indicates strong catalysts. Grade C (40-59) indicates moderate catalyst activity. Grade D (20-39) indicates weak catalysts. Grade F (0-19) indicates minimal near-term catalyst potential.
The Catalyst Grade simplifies the quantitative BTS Catalyst Score into an actionable letter rating that investors can quickly scan across hundreds of companies. According to BiotechSigns data, Grade A companies typically have multiple positive signals converging — such as an approaching PDUFA date with concurrent insider buying and strong clinical trial momentum — while Grade F companies may be in early-stage development with no near-term binary events.
BiotechSigns recalculates Catalyst Grades daily for every company in its coverage universe of 970+ biotech and pharmaceutical companies. The grade can change rapidly when new signals fire — for example, a company receiving an unexpected PDUFA date assignment or showing a cluster of insider buying activity may see its grade upgrade by one or more levels.
The Catalyst Grade is displayed on every company profile, the screener, and the leaderboard on the BiotechSigns homepage. The screener at biotechsign.com/app/screener allows filtering by grade, making it easy to focus on companies with the strongest catalyst profiles. Data sourced from SEC EDGAR, FDA.gov, ClinicalTrials.gov, and DilutionWatch.com.