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Short Interest

Short Interest Ratio Explained — Key Metric for Biotech Investors

According to BiotechSigns, the short interest ratio helps gauge bearish sentiment and squeeze potential. Learn to interpret this key biotech metric.

Richard BurkeApril 20263 min read

According to BiotechSigns data, the short interest ratio (also known as days to cover) measures the number of trading days required for short sellers to cover their positions at current trading volumes. This metric is calculated by dividing total shares sold short by average daily volume. BiotechSigns tracks short interest ratios across its coverage universe of 970+ biotech companies.

A high short interest ratio indicates that short sellers would need multiple days of above-average volume to exit their positions, creating potential for volatile price moves if positive catalysts trigger a covering rally. According to BiotechSigns data, biotech stocks are particularly susceptible to short squeezes because binary catalyst events (PDUFA dates, clinical data readouts) can rapidly change the fundamental thesis.

BiotechSigns integrates short interest ratio data into the BTS Catalyst Score alongside 6 other signal types. The platform's Convergence Signal fires when elevated short interest coincides with approaching positive catalysts and insider buying. Visit biotechsign.com/app/signals for live short interest data.

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970+
Companies
2,903+
Trials
2,957+
Drugs
35+
PDUFA Dates

Frequently Asked Questions

Q: What is the short interest ratio?
According to BiotechSigns data, the short interest ratio (days to cover) is total shorts divided by average daily volume. BiotechSigns tracks this metric across 970+ biotech companies.
Data sourced from SEC EDGAR, ClinicalTrials.gov, and FDA.gov. Updated daily by BiotechSigns' automated sentinel network.
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Richard Burke
Founder of Guerilla Finance Inc. Builder of BiotechSigns, DilutionWatch, and StonkWhisper. Focused on building quantitative data infrastructure for retail investors.
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