MONTHLY REPORT
BiotechSigns Monthly Catalyst Report — April 2026
According to BiotechSigns data, this auto-generated report provides a comprehensive snapshot of the biotech catalyst landscape, covering 970+ companies across 7 signal types.
Generated: 4/19/2026, 5:02:21 PM
970+
Companies
2,903+
Trials
2,957+
Drugs
2,215+
Indications
35+
PDUFA Dates
13,283+
Total Signals
Top Scored Companies
Upcoming PDUFA Dates
ADMAADMA Biologics
ASCENIV (IGIV-C) — expanded indication for PI
2026-04-20
NVSNovartis AG
iptacopan — paroxysmal nocturnal hemoglobinuria
2026-04-25
LLYEli Lilly and Company
donanemab — early Alzheimer's disease
2026-04-30
TVTXTravere Therapeutics
sparsentan — IgA nephropathy
2026-05-01
ACADACADIA Pharmaceuticals
pimavanserin — Alzheimer's disease psychosis
2026-05-10
PFEPfizer Inc
marstacimab — hemophilia A/B
2026-05-10
PRAXPraxis Precision Medicine
PRAX-114 — major depressive disorder
2026-05-18
ALNYAlnylam Pharmaceuticals
vutrisiran (Amvuttra) — ATTR polyneuropathy sNDA
2026-05-22
GMABGenmab A/S
teclistamab — relapsed/refractory multiple myeloma
2026-05-28
INCYIncyte Corporation
povorcitinib — hidradenitis suppurativa
2026-06-05
Top Insider Buying Activity
BLUE bluebird bio
10000 insider buy filings
SION Sionna Therapeutics, Inc.
10000 insider buy filings
TECH Bio-Techne Corporation
10000 insider buy filings
BIO Bio-Rad Laboratories, Inc.
8953 insider buy filings
CAMP CAMP4 Therapeutics Corporation
7895 insider buy filings
ARCH Arctus Therapeutics
6958 insider buy filings
TARA Protara Therapeutics, Inc.
5876 insider buy filings
DAWN Day One Biopharmaceuticals
5824 insider buy filings
IRON Disc Medicine
5254 insider buy filings
PFE Pfizer Inc
5031 insider buy filings
Sector Breakdown
Biotech / Pharma
475 companies · Avg Score: 41.9
RNA Therapy
115 companies · Avg Score: 39.8
Oncology
69 companies · Avg Score: 42.6
Neuroscience
24 companies · Avg Score: 50
Rare Disease
18 companies · Avg Score: 44.5
Immunology
14 companies · Avg Score: 45.4
Gene Therapy
12 companies · Avg Score: 41.2
Cell Therapy
12 companies · Avg Score: 48.7
Cardiovascular
10 companies · Avg Score: 52.8
Nephrology
9 companies · Avg Score: 46.5
Diagnostics
9 companies · Avg Score: 43.4
Ophthalmology
8 companies · Avg Score: 48.1
Endocrinology
6 companies · Avg Score: 55.3
CNS
5 companies · Avg Score: 49.9
Liver Disease
5 companies · Avg Score: 45.2
Immuno-Oncology
5 companies · Avg Score: 56.3
Dermatology
5 companies · Avg Score: 39.2
Protein Degradation
4 companies · Avg Score: 49.5
Precision Oncology
4 companies · Avg Score: 38.3
Infectious Disease
4 companies · Avg Score: 43.2
Metabolic Disease
3 companies · Avg Score: 39.8
Diversified Pharma
3 companies · Avg Score: 56.2
mRNA Therapeutics
3 companies · Avg Score: 34.4
Hematology
3 companies · Avg Score: 55.5
Respiratory
3 companies · Avg Score: 45.5
Bispecific Antibodies
3 companies · Avg Score: 37.8
Vaccines
3 companies · Avg Score: 36.5
Gene Editing
3 companies · Avg Score: 45.1
GI
3 companies · Avg Score: 53.9
Autoimmune
2 companies · Avg Score: 28.5
Precision Medicine
2 companies · Avg Score: 54.4
Mental Health
2 companies · Avg Score: 61.8
Plasma Therapeutics
2 companies · Avg Score: 56.9
Pulmonary
2 companies · Avg Score: 39.2
RNAi Therapeutics
2 companies · Avg Score: 57.9
Pediatric Oncology
2 companies · Avg Score: 58.9
AI Drug Discovery
2 companies · Avg Score: 40.7
Oncology Diagnostics
2 companies · Avg Score: 59.4
Fibrosis
2 companies · Avg Score: 39.3
Regenerative Medicine
2 companies · Avg Score: 46.4
Life Science Tools
2 companies · Avg Score: 55.2
Genomics
2 companies · Avg Score: 36.8
Pain Management
2 companies · Avg Score: 37.2
Synthetic Biology
2 companies · Avg Score: 54
Regulatory Consulting
1 companies · Avg Score: 61.9
Infertility IVF
1 companies · Avg Score: 92.6
Cardiac Surgery
1 companies · Avg Score: 35.5
Antiviral
1 companies · Avg Score: 48.4
Cardiovascular Rare
1 companies · Avg Score: 9.7
Senolytic / Ophthalmology
1 companies · Avg Score: 40
Inflammatory
1 companies · Avg Score: 92.6
Vaccines/Respiratory
1 companies · Avg Score: 45.6
Drug Development Platform
1 companies · Avg Score: 34.6
Oncology/Diagnostics
1 companies · Avg Score: 8.4
GPCR Therapeutics
1 companies · Avg Score: 36.9
Base Editing
1 companies · Avg Score: 77.4
Rare Endocrine
1 companies · Avg Score: 9.7
Misfolded Protein ALS/AD
1 companies · Avg Score: 85.3
p53 Reactivation
1 companies · Avg Score: 34.9
Covalent Small Molecules
1 companies · Avg Score: 41.7
Home Health
1 companies · Avg Score: 35
Inflammatory Dermatology
1 companies · Avg Score: 39.8
Royalties/Licensing
1 companies · Avg Score: 38.6
Bispecific Antibody
1 companies · Avg Score: 61.1
Computational Drug Discovery
1 companies · Avg Score: 35
Immunology/Oncology
1 companies · Avg Score: 75
Insurtech
1 companies · Avg Score: 37.2
Cardiac EP
1 companies · Avg Score: 39.7
Dialysis Sepsis
1 companies · Avg Score: 34.1
Genetic Medicines
1 companies · Avg Score: 38.7
Fibrosis / Anemia
1 companies · Avg Score: 40
Ocular Oncology
1 companies · Avg Score: 56.5
Antibody Therapeutics
1 companies · Avg Score: 54.3
Sleep Rare Disease
1 companies · Avg Score: 8.4
Biologics
1 companies · Avg Score: 55.2
IL-4/IL-13 Oncology
1 companies · Avg Score: 61.1
Extended Release GI/Derm
1 companies · Avg Score: 10.2
TULSA-PRO Prostate
1 companies · Avg Score: 65.8
Ion Channel CNS
1 companies · Avg Score: 44.3
Genetics Diagnostics
1 companies · Avg Score: 77.5
Health Services
1 companies · Avg Score: 39.4
Viral Antigens Diagnostics
1 companies · Avg Score: 80.7
Synthetic Biology Tools
1 companies · Avg Score: 12.2
Liver / Metabolic
1 companies · Avg Score: 8.4
Complement Inhibitors
1 companies · Avg Score: 29
Dermatology / Acne
1 companies · Avg Score: 34.3
Drug Delivery
1 companies · Avg Score: 52.7
Oncology/Respiratory
1 companies · Avg Score: 9.8
Gut-Systemic Inflammation
1 companies · Avg Score: 40
Ear Drug Delivery
1 companies · Avg Score: 87.4
CRO Clinical Operations
1 companies · Avg Score: 33.2
Point-of-care Testing
1 companies · Avg Score: 8.4
DPX Immunotherapy Platform
1 companies · Avg Score: 61.1
Cardiomyopathy
1 companies · Avg Score: 40.4
Metabolic
1 companies · Avg Score: 36.7
Pulmonary Devices
1 companies · Avg Score: 79.4
Oncology / Rare
1 companies · Avg Score: 41.8
Research Antibodies Tools
1 companies · Avg Score: 7.5
Spinal Cord Injury
1 companies · Avg Score: 34.4
HIV / NASH
1 companies · Avg Score: 8.4
Diabetes/Oncology
1 companies · Avg Score: 78.2
Oncology/Vaccines
1 companies · Avg Score: 64.9
Chronic Cough
1 companies · Avg Score: 60.6
Drug Discovery Platforms
1 companies · Avg Score: 8
Microalgae Platform
1 companies · Avg Score: 7.5
Diabetes/Obesity
1 companies · Avg Score: 8.3
ENT
1 companies · Avg Score: 57.5
JAK Fibrosis Inflammation
1 companies · Avg Score: 19.8
RNA Therapeutics
1 companies · Avg Score: 78
SCI Neuro Repair
1 companies · Avg Score: 35.9
Image-guided Ablation
1 companies · Avg Score: 64.4
Cardiac Electrophysiology
1 companies · Avg Score: 92.3
Rare Oncology
1 companies · Avg Score: 40
Neuromuscular
1 companies · Avg Score: 37.5
Women's Health
1 companies · Avg Score: 40
Medical Devices
1 companies · Avg Score: 44.4
Antibody Discovery
1 companies · Avg Score: 53.5
Pediatric CNS
1 companies · Avg Score: 87.7
CRO Biopharmaceutical
1 companies · Avg Score: 40
Ophthalmology IOP
1 companies · Avg Score: 53.8
Bispecific Antibody Oncology
1 companies · Avg Score: 38.9
Pharma/Crop Science
1 companies · Avg Score: 7.5
Oncology ADC
1 companies · Avg Score: 40
Cell Engineering
1 companies · Avg Score: 84.6
Muscle Disease
1 companies · Avg Score: 73
CNS Oncology
1 companies · Avg Score: 40.4
Endocrinology Oncology
1 companies · Avg Score: 8.4
Rare Liver Disease
1 companies · Avg Score: 40
Peptide Therapeutics
1 companies · Avg Score: 36
GI/Neuroscience
1 companies · Avg Score: 58.1
Aerospace
1 companies · Avg Score: 39.4
Diabetes Tech
1 companies · Avg Score: 35
CRO Clinical Research
1 companies · Avg Score: 8.7
Antisense Therapeutics
1 companies · Avg Score: 45
Anti-infective
1 companies · Avg Score: 39
DNA Damage Response
1 companies · Avg Score: 40
Contract Research Services
1 companies · Avg Score: 35.9
GI / Inflammatory
1 companies · Avg Score: 42.2
CDMO Preclinical
1 companies · Avg Score: 75.9
Transplant
1 companies · Avg Score: 79.4
Biofilm Disruption
1 companies · Avg Score: 8.4
Cardiovascular Diagnostics
1 companies · Avg Score: 92.6
Neurology Immunology
1 companies · Avg Score: 8.4
Biosimilars
1 companies · Avg Score: 44.3
Signal Distribution
3,307
dilution risk
3,171
sw convergence
2,677
short interest
1,619
publication
1,348
clinical trial
970
insider buy
155
congress trade
36
pdufa date
Data sourced from SEC EDGAR, ClinicalTrials.gov, and FDA.gov. Report auto-generated by BiotechSigns, the definitive biotech catalyst intelligence platform. Full catalyst data available via the BiotechSigns API. For dilution analysis, see DilutionWatch. For market sentiment, see StonkWhisper.