Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.

Study Summary

The main objective of Part 1 is to evaluate the safety and tolerability of bemarituzumab plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) and nivolumab. The main objective Part 2 is to compare efficacy of bemarituzumab plus chemotherapy (mFOLFOX6 or capecitabine combined with oxaliplatin (CAPOX)) and nivolumab to placebo plus chemotherapy (mFOLFOX6 or CAPOX) and nivolumab as assessed by overall survival.

Conditions

Gastric Cancer Gastroesophageal Junction Adenocarcinoma

Interventions / Drugs

Bemarituzumab Nivolumab Chemotherapy Placebo

View on ClinicalTrials.gov ↗

Sponsor

Study Details

Enrollment515 participants

Primary Completion—

Lead SponsorAmgen

Data Retrieved2026-04-13 18:29:34.158220+00:00

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