A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension

Study Summary

This study is to assess the pharmacokinetics (PK) and safety of SC pembrolizumab (+) berahyaluronidase alfa vs intravenous (IV) pembrolizumab, administered with chemotherapy in first line treatment of adult Japanese participants with metastatic non-small cell lung cancer. The primary hypotheses of this study are pembrolizumab (+) berahyaluronidase alfa subcutaneous (SC) is noninferior to pembrolizumab IV with respect to PK parameters.

Conditions

Metastatic Non-small Cell Lung Cancer

Interventions / Drugs

Pembrolizumab (+) Berahyaluronidase alfa Pemetrexed Cisplatin Carboplatin Paclitaxel Nab-paclitaxel Pembrolizumab Filgrastim Pegylated filgrastim

View on ClinicalTrials.gov ↗

Sponsor

Study Details

Enrollment39 participants

Primary Completion—

Lead SponsorMerck Sharp & Dohme LLC

Data Retrieved2026-04-11 02:55:36.205189+00:00

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